{"id":12838,"date":"2022-11-09T09:11:56","date_gmt":"2022-11-09T13:11:56","guid":{"rendered":"https:\/\/afcomunicacion.com\/uncategorized\/cleveland-clinic-trial-finds-six-widely-used-dietary-supplements-do-not-lower-cholesterol-compared-with-statin-or-placebo\/"},"modified":"2022-11-09T09:11:56","modified_gmt":"2022-11-09T13:11:56","slug":"cleveland-clinic-trial-finds-six-widely-used-dietary-supplements-do-not-lower-cholesterol-compared-with-statin-or-placebo","status":"publish","type":"post","link":"https:\/\/afcomunicacion.com\/en\/blog-en\/cleveland-clinic-trial-finds-six-widely-used-dietary-supplements-do-not-lower-cholesterol-compared-with-statin-or-placebo\/","title":{"rendered":"Cleveland Clinic clinical trial finds six widely used dietary supplements do not lower cholesterol compared with a low-dose statin or placebo"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li><em>SPORT Trial presented at the American Heart Association Scientific Sessions 2022.<\/em><\/li>\n<\/ul>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><strong>Cleveland, November 2022<\/strong>. Results from a<strong><mark style=\"color:#138c00\" class=\"has-inline-color\"> Cleveland Clinic<\/mark><\/strong> trial show that, compared with a low-dose cholesterol-lowering medication (also known as a statin) or <strong>placebo<\/strong>, six dietary supplements commonly taken to improve heart health did not lower &#8220;bad cholesterol&#8221;. The six supplements studied were fish oil, garlic, cinnamon, turmeric, plant sterols and red yeast rice.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Results from the <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">Supplements, Placebo or Rosuvastatin Study (SPORT)<\/mark><\/strong> were presented during a late-breaking science session at the <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">American Heart Association Scientific Sessions<\/mark><\/strong> 2022 and published simultaneously in the Journal of the<strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\"> A<\/mark><\/strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\"><strong>merican College of Cardiology<\/strong><\/mark>.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">&#8220;If you are taking over-the-counter supplements for heart health or to lower cholesterol, you should reconsider the treatment,&#8221; said <strong>Dr. Luke Laffin<\/strong>, study author and co-director of the Center for Blood Pressure Disorders in <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic&#8217;s<\/mark><\/strong> <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">Heart, Vascular &amp; Thoracic Institute<\/mark><\/strong>. &#8220;<strong>Unfortunately, many US consumers believe that cholesterol health supplements are safer than prescription medications and believe supplements are as effective as, or more effective than, statins.&#8221;<\/strong><\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">The marketing of dietary supplements is regulated by the<strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\"> Dietary Supplement Health and Education Ac<\/mark><\/strong>t of 1994 and overseen by the <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">US Federal Trade Commission<\/mark><\/strong> rather than the Food and Drug Administration. Supplements therefore do not need to meet the safety and efficacy standards required for marketing pharmaceutical products.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Elevated low-density lipoprotein<strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\"> (LDL)<\/mark><\/strong>, also known as &#8220;bad cholesterol&#8221;, is a major cause of coronary heart disease. <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">LDL<\/mark><\/strong> cholesterol causes fatty deposits to build up inside the arteries, reducing or blocking the flow of blood and oxygen the heart needs. This can lead to a heart attack or stroke. <strong>Many studies show that lowering LDL cholesterol reduces the risk of coronary heart disease<\/strong>.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">In the single-centre, prospective, randomised clinical trial, researchers analysed health data from 190 adults aged 40 to 75 with no history of cardiovascular disease. Participants were randomly assigned to a low dose of the statin medication rosuvastatin (5 mg daily), placebo, fish oil, cinnamon, garlic, turmeric, plant sterols or red yeast rice. The primary endpoint was the percentage change in <mark style=\"color:#0b5d8c\" class=\"has-inline-color\"><strong>LDL <\/strong><\/mark>cholesterol from baseline for rosuvastatin 5 mg daily compared with placebo and each supplement after 28 days.<\/p>\n\n\n\n<p class=\"has-text-align-justify has-black-color has-text-color wp-block-paragraph\">The results showed that the percentage reduction in <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">LDL <\/mark><\/strong>cholesterol with rosuvastatin was greater than with all the supplements and placebo. None of the dietary supplements showed a significant decrease in <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">LDL <\/mark><\/strong>cholesterol compared with placebo. Rosuvastatin also had a beneficial impact on blood triglycerides and total cholesterol, which helps reduce cardiovascular risk.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">The average reduction in <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">LDL <\/mark><\/strong>cholesterol after 28 days was 37.9% among participants taking the statin, while changes in <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">LDL <\/mark><\/strong>cholesterol levels among those taking any of the dietary supplements were similar to the placebo group. Participants in the statin group had an average 24% decrease in total cholesterol, <strong>while neither the placebo group nor any of the dietary supplements showed any benefit.<\/strong> Rosuvastatin produced a 19% decrease in blood triglycerides compared with placebo, but there was no difference in triglycerides for any of the dietary supplements.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Rates of adverse events were similar across all groups, although numerically higher among participants randomised to plant sterols or red yeast rice. In addition, no significant adverse changes were seen in liver function tests, estimated glomerular filtration rate or blood glucose with rosuvastatin.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2022\/11\/Doctor-Steven-Nissen-director-academico-del-Instituto-Vascular-y-Toracico-de-Cleveland-Clinic.-.jpg\" alt=\"\" class=\"wp-image-7552\" width=\"276\" height=\"276\" srcset=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2022\/11\/Doctor-Steven-Nissen-director-academico-del-Instituto-Vascular-y-Toracico-de-Cleveland-Clinic.-.jpg 600w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2022\/11\/Doctor-Steven-Nissen-director-academico-del-Instituto-Vascular-y-Toracico-de-Cleveland-Clinic.--300x300.jpg 300w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2022\/11\/Doctor-Steven-Nissen-director-academico-del-Instituto-Vascular-y-Toracico-de-Cleveland-Clinic.--150x150.jpg 150w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-justify has-black-color has-text-color wp-block-paragraph\"><strong>&#8220;Dietary supplement sales are estimated at almost $50 billion a year in the United States, and many supplements are marketed as natural alternatives for heart protection and cholesterol management,&#8221;<\/strong> said senior author Dr. Steven Nissen, Chief Academic Officer of <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic&#8217;s<\/mark><\/strong> <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">Heart, Vascular &amp; Thoracic Institute<\/mark><\/strong>. &#8220;For managing high cholesterol, supplements are often used by patients instead of statins, in the absence of high-quality data. <strong>This represents a major public health concern.&#8221;<\/strong><\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">The <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">SPORT<\/mark><\/strong> trial <strong>was funded by AstraZeneca<\/strong> through an unrestricted grant. <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic <\/mark><\/strong>has full control over the study methodology, data analysis and discussion of clinical implications.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Dr. Laffin has served as a consultant or steering committee member for Medtronic, Eli Lilly, Mineralys Therapeutics and AstraZeneca. He is also an adviser to LucidAct Health and Gordy Health.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Dr. Nissen has been a consultant for many pharmaceutical companies and has overseen clinical trials for Amgen, AstraZeneca, Cerenis, Eli Lilly, Novartis, Novo Nordisk, The Medicines Company, Orexigen, Takeda and Pfizer. However, he does not accept honoraria, consulting fees or other compensation from commercial entities.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p class=\"wp-block-paragraph\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"47\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2022\/03\/Cleveland_Clinic_logo_color-300x47.png\" alt=\"\"><\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><strong>About Cleveland Clinic<\/strong><\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> is a nonprofit multispecialty academic medical centre that integrates clinical and hospital care with research and education. Located in <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland<\/mark><\/strong>, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based on the principles of cooperation, compassion and innovation. <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States.  <\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><em>U.S. News &amp; World Report<\/em> consistently names <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> as one of the nation&#8217;s best hospitals in its annual &#8220;America&#8217;s Best Hospitals&#8221; survey. Among <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic&#8217;s<\/mark><\/strong> 72,500 employees worldwide are more than 5,050 salaried physicians and researchers, and 17,800 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties.  <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> is a 6,500-bed health system that includes a 173-acre main campus near downtown Cleveland, 21 hospitals, more than 220 outpatient facilities, and locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. <\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"> In 2021, there were 10.2 million outpatient visits, 304,000 hospital admissions and observations, and 259,000 surgeries across <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic&#8217;s<\/mark><\/strong> health system. Patients came for treatment from every state and 185 countries.  <\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Visit us at <mark style=\"color:#138c00\" class=\"has-inline-color\"><span style=\"text-decoration: underline\">clevelandclinic.org<\/span><\/mark>. Follow us at twitter.com\/<mark style=\"color:#138c00\" class=\"has-inline-color\"><span style=\"text-decoration: underline\">ClevelandClinic<\/span><\/mark>. News and resources available at<mark style=\"color:#138c00\" class=\"has-inline-color\"><span style=\"text-decoration: underline\"> newsroom.clevelandclinic.org<\/span><\/mark>.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><em>Find out more about <mark><a href=\"https:\/\/afcomunicacion.com\/nosotros\/\"><mark style=\"background-color:#ffffff;color:#0b5d8c\" class=\"has-inline-color\">AF Comunicaci\u00f3n Estrat\u00e9gica<\/mark><\/a><mark style=\"background-color:#ffffff\" class=\"has-inline-color\"><a href=\"https:\/\/afcomunicacion.com\/nosotros\/\"> <\/a>and <\/mark><a href=\"https:\/\/afcomunicacion.com\/nuestros-clientes\/\"><mark style=\"background-color:#ffffff;color:#0b5d8c\" class=\"has-inline-color\">its clients<\/mark><\/a><\/mark><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cleveland, November 2022. Results from a Cleveland Clinic trial show that, compared with a low-dose cholesterol-lowering medication (also known as a statin) or placebo, six dietary supplements commonly taken to improve heart health did not lower &#8220;bad cholesterol&#8221;. The six supplements studied were fish oil, garlic, cinnamon, turmeric, plant sterols and red yeast rice. Results [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":7549,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[485,486],"tags":[2813,2814,2230,2815,2816,2817,2818,2819,2820],"class_list":["post-12838","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en","category-press-room","tag-american-college-of-cardiology-en","tag-astrazeneca-en","tag-cleveland-en","tag-comision-federal-de-comercio-de-ee-uu-en","tag-instituto-cardiaco-vascular-y-toracico-en","tag-ldl-en","tag-sesiones-cientificas-de-la-asociacion-americana-del-corazon-en","tag-sport-en","tag-sport-trial-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.3 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cleveland Clinic clinical trial finds six widely used dietary supplements do not lower cholesterol 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