{"id":12858,"date":"2023-01-19T09:47:06","date_gmt":"2023-01-19T13:47:06","guid":{"rendered":"https:\/\/afcomunicacion.com\/uncategorized\/cleveland-clinic-study-reveals-new-ways-the-gut-microbiome-contributes-to-heart-disease-risk\/"},"modified":"2023-01-19T09:47:06","modified_gmt":"2023-01-19T13:47:06","slug":"cleveland-clinic-study-reveals-new-ways-the-gut-microbiome-contributes-to-heart-disease-risk","status":"publish","type":"post","link":"https:\/\/afcomunicacion.com\/en\/blog-en\/cleveland-clinic-study-reveals-new-ways-the-gut-microbiome-contributes-to-heart-disease-risk\/","title":{"rendered":"Cleveland Clinic study reveals new ways the gut microbiome contributes to heart disease risk"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li><em>This study substantially expands the potential links between our diet and how our gut microbiome acts as a filter, affecting our susceptibility to developing different diseases.<\/em><\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2023\/01\/Nivel-altos-microbioma-intestinal-contribuye-a-los-riesgos-de-enfermedad-cardiaca.jpg\" alt=\"\" class=\"wp-image-7735\" width=\"325\" height=\"203\" srcset=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2023\/01\/Nivel-altos-microbioma-intestinal-contribuye-a-los-riesgos-de-enfermedad-cardiaca.jpg 960w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2023\/01\/Nivel-altos-microbioma-intestinal-contribuye-a-los-riesgos-de-enfermedad-cardiaca-300x188.jpg 300w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2023\/01\/Nivel-altos-microbioma-intestinal-contribuye-a-los-riesgos-de-enfermedad-cardiaca-768x480.jpg 768w\" sizes=\"auto, (max-width: 325px) 100vw, 325px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><strong>January 2023<\/strong>.- New research at <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> expands the link between what we eat and how the gut microbiome affects our susceptibility to developing different diseases \u2013 in this case, how a specific by-product generated by gut microbes is linked to heart failure risk.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Elevated levels of phenylacetylglutamine<strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\"> (PAG)<\/mark><\/strong>, a by-product created when microbes in the gut break down dietary protein, may be directly linked to a higher risk and severity of heart failure, according to findings published in<strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\"> <em><u>Circulation: Heart Failure<\/u><\/em>.<\/mark><\/strong><\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">The new findings improve researchers&#8217; understanding of how the gut microbiome, through <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG<\/mark><\/strong> levels, is linked to heart disease risk, and suggest potential approaches for modifying <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG<\/mark><\/strong>-associated risk through interventions such as diet and the use of beta blockers.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Elevated <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG <\/mark><\/strong>levels were also shown to correspond with types of heart failure. For example, elevated blood <mark style=\"color:#0b5d8c\" class=\"has-inline-color\"><strong>PAG <\/strong><\/mark>was seen in subjects with heart failure with preserved ejection fraction, a condition in which the heart muscle doesn&#8217;t relax enough between beats and becomes too stiff, making it less able to fill with and, in turn, pump blood.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">&#8220;Measuring blood levels of <strong>PAG <\/strong>could provide remarkable value in predicting who is at risk of heart failure,&#8221;<\/mark> says <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">Dr. Stanley Hazen<\/mark><\/strong>, chair of the Department of Cardiovascular and Metabolic Sciences at the Lerner Research Institute. &#8220;The data build a strong case that making this test available to physicians would add to their arsenal of diagnostic tests for heart failure.&#8221;<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">A team led by <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">Dr. Hazen<\/mark><\/strong>, who also serves as co-section head of Preventive Cardiology, previously discovered the link between <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG <\/mark><\/strong>and cardiovascular disease, including the risk of heart attack, stroke and death, in a 2020 study. In that study, <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG <\/mark><\/strong>was shown to affect the function of adrenergic receptors on platelets, affecting functions such as blood clotting risk.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">This new study delved into other potential roles of <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG <\/mark><\/strong>with a focus on heart failure. The research team found that <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG<\/mark><\/strong> levels were linked to heart failure risk through data from thousands of patients in two independent study cohorts, one from Europe and one from the United States. In further studies, introducing <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG <\/mark><\/strong>to heart cells in the lab allowed researchers to better understand the mechanism behind <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG&#8217;s <\/mark><\/strong>association with heart failure and a basis for counteracting its effects.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">&#8220;This study substantially expands the potential links between our diet and how our gut microbiome acts as a filter of our diet, affecting our susceptibility to developing different diseases,&#8221; says<strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\"> Dr. Hazen<\/mark><\/strong>. &#8220;In this case, gut microbes form a metabolite of the amino acid phenylalanine in dietary protein, which adversely affects the function of a beating heart muscle cell.&#8221;<\/p>\n\n\n\n<h4 class=\"has-black-color has-text-color wp-block-heading\"><strong>Targeting PAG to address a critical health condition<\/strong><\/h4>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">Around 6.2 million American adults have heart failure, a condition in which the heart cannot pump enough blood and oxygen to meet the body&#8217;s needs. Existing treatments include lifestyle changes, such as reducing sodium, or medication.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">&#8220;Despite the latest advances in drug and device therapies, heart failure remains one of the leading causes of death and hospital admissions in the United States and around the world,&#8221; <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">says Wai Hong Wilson Tang, director of heart failure and transplant research in the Department of Cardiovascular Medicine at <\/mark><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><mark style=\"color:#0b5d8c\" class=\"has-inline-color\"> and co-author of the paper<\/mark><\/strong>. &#8220;These studies suggest it is worth exploring a better understanding of how we can modify PAG levels and reduce the risk of heart failure.&#8221;<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">In the initial <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG <\/mark><\/strong>studies in 2020, <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">Drs. Hazen, Tang and colleague<\/mark><\/strong>s showed how <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG <\/mark><\/strong>affects multiple adrenergic receptors on cells, including the beta-adrenergic receptor targeted by beta blockers. Those studies included evidence of using drugs such as carvedilol to counteract the effects of <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG<\/mark><\/strong>.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\">One of the next steps <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">Dr. Hazen&#8217;s<\/mark><\/strong> team is focusing on is identifying the bacteria and their enzymes that help produce <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG <\/mark><\/strong>and developing therapeutic approaches to lower <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">PAG<\/mark><\/strong>. Dietary interventions could also potentially help reduce risk, <mark style=\"color:#0b5d8c\" class=\"has-inline-color\">says<\/mark> <strong><mark style=\"color:#0b5d8c\" class=\"has-inline-color\">Dr. Hazen.<\/mark><\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p class=\"wp-block-paragraph\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"47\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2022\/03\/Cleveland_Clinic_logo_color-300x47.png\" alt=\"\"><\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><strong>About Cleveland Clinic<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-justify has-black-color has-text-color wp-block-paragraph\"><strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> is a nonprofit multispecialty academic medical centre that integrates clinical and hospital care with research and education. Located in <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland<\/mark><\/strong>, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based on the principles of cooperation, compassion and innovation. <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. &nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-justify has-black-color has-text-color wp-block-paragraph\"><em>U.S. News &amp; World Report<\/em> consistently names <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> as one of the nation&#8217;s best hospitals in its annual &#8220;America&#8217;s Best Hospitals&#8221; survey. Among <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic&#8217;s<\/mark><\/strong> 72,500 employees worldwide are more than 5,050 salaried physicians and researchers, and 17,800 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. &nbsp;<strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> is a 6,500-bed health system that includes a 173-acre main campus near downtown Cleveland, 21 hospitals, more than 220 outpatient facilities, and locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. <\/p>\n\n\n\n<p class=\"has-text-align-justify has-black-color has-text-color wp-block-paragraph\">&nbsp;In 2021, there were 10.2 million outpatient visits, 304,000 hospital admissions and observations, and 259,000 surgeries across <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic&#8217;s<\/mark><\/strong> health system. Patients came for treatment from every state and 185 countries. &nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-justify has-black-color has-text-color wp-block-paragraph\">Visit us at <mark style=\"color:#138c00\" class=\"has-inline-color\"><span style=\"text-decoration: underline\">clevelandclinic.org<\/span><\/mark>. Follow us at twitter.com\/<mark style=\"color:#138c00\" class=\"has-inline-color\"><span style=\"text-decoration: underline\">ClevelandClinic<\/span><\/mark>. News and resources available at<mark style=\"color:#138c00\" class=\"has-inline-color\"><span style=\"text-decoration: underline\"> newsroom.clevelandclinic.org<\/span><\/mark>.<\/p>\n\n\n\n<p class=\"has-black-color has-text-color wp-block-paragraph\"><em>Find out more about <mark><a href=\"https:\/\/afcomunicacion.com\/nosotros\/\"><mark style=\"background-color:#ffffff;color:#0b5d8c\" class=\"has-inline-color\"><span style=\"text-decoration: underline\">AF Comunicaci\u00f3n Estrat\u00e9gica<\/span><\/mark><\/a><mark style=\"background-color:#ffffff\" class=\"has-inline-color\"><a href=\"https:\/\/afcomunicacion.com\/nosotros\/\"> <\/a>and&nbsp;<\/mark><a href=\"https:\/\/afcomunicacion.com\/nuestros-clientes\/\"><mark style=\"background-color:#ffffff;color:#0b5d8c\" class=\"has-inline-color\"><span style=\"text-decoration: underline\">its clients<\/span><\/mark><\/a><\/mark><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>January 2023.- New research at Cleveland Clinic expands the link between what we eat and how the gut microbiome affects our susceptibility to developing different diseases \u2013 in this case, how a specific by-product generated by gut microbes is linked to heart failure risk. Elevated levels of phenylacetylglutamine (PAG), a by-product created when microbes in [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":7733,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[485],"tags":[2896,2230,2897,2898,2899,2900,2901],"class_list":["post-12858","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en","tag-circulation-heart-failure-en","tag-cleveland-en","tag-enfermedad-cardiaca-en","tag-intervencion-dietetica-en","tag-medicina-cardiovascular-en","tag-microbioma-intestinal-en","tag-pag-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.3 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cleveland Clinic study reveals new ways the gut microbiome contributes to heart disease risk - AF Comunicaci\u00f3n Estrat\u00e9gica<\/title>\n<meta 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