{"id":12966,"date":"2024-02-16T09:31:43","date_gmt":"2024-02-16T13:31:43","guid":{"rendered":"https:\/\/afcomunicacion.com\/uncategorized\/cleveland-clinic-research-finds-unique-tumour-related-bacteria-associated-with-early-onset-colorectal-cancer\/"},"modified":"2024-02-16T09:31:43","modified_gmt":"2024-02-16T13:31:43","slug":"cleveland-clinic-research-finds-unique-tumour-related-bacteria-associated-with-early-onset-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-research-finds-unique-tumour-related-bacteria-associated-with-early-onset-colorectal-cancer\/","title":{"rendered":"Cleveland Clinic research finds unique tumour-related bacteria associated with early-onset colorectal cancer"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li><em>The discovery could lead to new tests and treatments for people under 50.<\/em><\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"680\" height=\"390\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Alok-Khorana-M.D.-oncologo-de-Cleveland-Clinic-e-investigador-principal-del-estudio.jpg\" alt=\"\" class=\"wp-image-9008\" style=\"width:467px;height:auto\" srcset=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Alok-Khorana-M.D.-oncologo-de-Cleveland-Clinic-e-investigador-principal-del-estudio.jpg 680w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Alok-Khorana-M.D.-oncologo-de-Cleveland-Clinic-e-investigador-principal-del-estudio-300x172.jpg 300w\" sizes=\"auto, (max-width: 680px) 100vw, 680px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">New research from <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> has mapped changes in the bacteria related to tumours associated with <a href=\"https:\/\/my.clevelandclinic.org\/services\/young-onset-colorectal-cancer-treatment?_gl=1*1rul8ks*_ga*MTg5OTEzMzMzNi4xNjg3MzgxMjk1*_ga_HWJ092SPKP*MTcwNzkzMTgzNS45My4xLjE3MDc5MzQ1NzQuMC4wLjA.\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>early-onset colorectal cancer<\/strong><\/a> to uncover potential new strategies to combat the rise of this type of cancer in people under 50.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research reveals unique differences in the bacteria related to tumours associated with early-onset <a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/14501-colorectal-colon-cancer?_gl=1*ix8u7f*_ga*MTg5OTEzMzMzNi4xNjg3MzgxMjk1*_ga_HWJ092SPKP*MTcwNzkzMTgzNS45My4xLjE3MDc5MzQ1ODAuMC4wLjA.\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>colorectal cancer<\/strong><\/a>. The findings, published in <strong>eBioMedicine <\/strong>(part of<strong> Lancet Discovery Science)<\/strong>, could lead to new tests or treatments for this segment of the population.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to the American Cancer Society, the incidence of and mortality from early-onset colorectal cancer have risen by 1.5% and 1.2% a year, respectively. If this trend continues, a report in the <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Journal of the National Cancer Institute<\/mark><\/strong> estimates that the incidence of colon cancer would double and <a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/21733-rectal-cancer?_gl=1*6q9b9s*_ga*MTg5OTEzMzMzNi4xNjg3MzgxMjk1*_ga_HWJ092SPKP*MTcwNzkzMTgzNS45My4xLjE3MDc5MzQ2NzAuMC4wLjA.\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>rectal cancer<\/strong><\/a> would quadruple in people under 50 by 2030.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"709\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Colorrectal-1024x709.jpg\" alt=\"\" class=\"wp-image-9010\" style=\"width:424px;height:auto\" srcset=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Colorrectal-1024x709.jpg 1024w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Colorrectal-300x208.jpg 300w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Colorrectal-768x531.jpg 768w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Colorrectal-1536x1063.jpg 1536w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Colorrectal.jpg 1695w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"color:#138c00\" class=\"has-inline-color\">&#8220;The unexplained rise in early-onset colorectal cancer is a major concern,&#8221;<\/mark> said Alok Khorana, M.D., an oncologist at <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic <\/mark><\/strong>and principal investigator of the study. <mark style=\"color:#138c00\" class=\"has-inline-color\">&#8220;Our team found that bacteria were more abundant and compositionally distinct in the tumours of early-onset patients. These insights help us better understand the causes of the disease and inform new approaches to prevention, diagnostic markers and therapeutic targets.&#8221;<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This retrospective study, <strong>funded by the family of Sondra and Stephen Hardis,<\/strong> used <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">genetic sequencing technology<\/mark><\/strong> to compare tissue samples from 136 patients with early-onset colorectal cancer with those from 140 average-age patients with the disease. They identified unique tumour-related bacteria in the younger sample and found that these patients were more likely to have left-sided, rectal and advanced-stage tumours. The main bacteria associated with early-onset <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">cancers<\/mark><\/strong> included <strong>Akkermansia and Bacteroides.<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Alok-Khorana-M.D.-oncologo-de-Cleveland-Clinic-1024x576.jpg\" alt=\"\" class=\"wp-image-9012\" style=\"width:563px;height:auto\" srcset=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Alok-Khorana-M.D.-oncologo-de-Cleveland-Clinic-1024x576.jpg 1024w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Alok-Khorana-M.D.-oncologo-de-Cleveland-Clinic-300x169.jpg 300w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Alok-Khorana-M.D.-oncologo-de-Cleveland-Clinic-768x432.jpg 768w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/02\/Alok-Khorana-M.D.-oncologo-de-Cleveland-Clinic.jpg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">The first authors of the paper were <strong>Shimoli Barot, M.D.,<\/strong> of the <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic Cancer Institute<\/mark><\/strong>, and <strong>Naseer Sangwan, Ph.D.<\/strong>, of the <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic Lerner Research Institute.<\/mark><\/strong> Dr. Khorana also holds the Sondra and Stephen Hardis Chair in <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Oncology Research.<\/mark><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"color:#138c00\" class=\"has-inline-color\">&#8220;By detailing this microbial signature of early-onset disease, we can look for new screening biomarkers and medicines that target the related bacteria,&#8221;<\/mark> said Dr. Barot.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Sangwan added that <mark style=\"color:#138c00\" class=\"has-inline-color\">&#8220;more research is needed on how lifestyle factors such as diet, medications and obesity may affect gut bacteria and contribute to early-onset colon cancers.&#8221;<\/mark><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"250\" height=\"250\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2019\/06\/Cleveland.jpg\" alt=\"Cleveland Clinic\" class=\"wp-image-2354\" style=\"width:211px;height:auto\" srcset=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2019\/06\/Cleveland.jpg 250w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2019\/06\/Cleveland-150x150.jpg 150w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>About Cleveland Clinic<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/my.clevelandclinic.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong><\/a> is a nonprofit multispecialty academic medical centre that integrates clinical and hospital care with research and education. Located in<strong><mark style=\"color:#138c00\" class=\"has-inline-color\"> Cleveland,<\/mark><\/strong> Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based on the principles of cooperation, compassion and innovation. <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. Among Cleveland Clinic&#8217;s 77,000 employees worldwide are more than 5,658 salaried physicians and researchers, and 19,000 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic<\/mark><\/strong> is a 6,699-bed health system that includes a 173-acre main campus near downtown <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland,<\/mark><\/strong> 23 hospitals, more than 275 outpatient facilities, including locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2022, there were 12.8 million outpatient encounters, 303,000 hospital admissions and observations, and 270,000 surgeries and procedures throughout <strong><mark style=\"color:#138c00\" class=\"has-inline-color\">Cleveland Clinic&#8217;s<\/mark><\/strong> health system. Patients came for treatment from every state and 185 countries.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The research reveals unique differences in the bacteria related to tumours associated with early-onset colorectal cancer. The findings, published in eBioMedicine (part of Lancet Discovery Science), could lead to new tests or treatments for this segment of the population.<\/p>\n","protected":false},"author":12,"featured_media":9010,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[486],"tags":[2228,3493,2230,3494,3495,2224],"class_list":["post-12966","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-room","tag-cancer-en","tag-cancer-colorrectal-en","tag-cleveland-en","tag-colorrectal-en","tag-inicio-temprano-en","tag-salud-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.6 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Understanding the rise in early-onset colorectal cancer - AF Comunicaci\u00f3n Estrat\u00e9gica<\/title>\n<meta name=\"description\" content=\"New strategies to combat the rise in early-onset colorectal cancer reported in eBioMedicine. 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