{"id":12972,"date":"2024-03-07T12:49:51","date_gmt":"2024-03-07T16:49:51","guid":{"rendered":"https:\/\/afcomunicacion.com\/uncategorized\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/"},"modified":"2024-03-07T12:49:51","modified_gmt":"2024-03-07T16:49:51","slug":"cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease","status":"publish","type":"post","link":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/","title":{"rendered":"Cleveland Clinic-led study finds link between high levels of niacin &#8211; a common B vitamin &#8211; and heart disease"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li><em>Excess niacin fuels inflammation and cardiovascular disease through a newly identified pathway.<\/em><\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg\" alt=\"Dr. Stanley Hazen, chair of Cardiovascular and Metabolic Sciences at Cleveland Clinic&apos;s Lerner Research Institute\" class=\"wp-image-9064\" style=\"width:806px;height:auto\" srcset=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg 1024w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-300x200.jpg 300w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-768x512.jpg 768w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1536x1024.jpg 1536w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-2048x1365.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-black-color\"><strong>Cleveland 2024: <\/strong><\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Cleveland Clinic<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> researchers have identified a <strong>new pathway <\/strong>that contributes to <strong>cardiovascular disease<\/strong> associated with <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">high levels of niacin,<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> a common <strong>B vitamin <\/strong>previously recommended for lowering cholesterol.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-black-color\">The team, led by <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Stanley Hazen, M.D., Ph.D.,<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> discovered a link between <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">4PY<\/mark><\/strong><mark class=\"has-inline-color has-black-color\">, a breakdown product of <strong>excess niacin, and heart disease.<\/strong> Higher circulating levels of <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">4PY<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> were strongly associated with the development of heart attacks, strokes and other adverse cardiac events in large-scale clinical studies. The researchers also showed in preclinical studies that <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">4PY <\/mark><\/strong><mark class=\"has-inline-color has-black-color\">directly triggers vascular inflammation, damaging blood vessels, which can lead to atherosclerosis over time.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-black-color\">The study, published in <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\"><em><u>Nature Medicine<\/u><\/em>,<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> also details genetic links between <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">4PY<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> and vascular inflammation. The findings provide a basis for potential new interventions and therapies to reduce or prevent that inflammation.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><mark class=\"has-inline-color has-vivid-cyan-blue-color\">&#8220;What&#8217;s exciting about these results is that this pathway appears to be a significant but previously unrecognised contributor to the development of cardiovascular disease,&#8221;<\/mark><\/em><mark class=\"has-inline-color has-black-color\"> said <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Dr. Hazen,<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> chair of Cardiovascular and Metabolic Sciences at <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Cleveland Clinic&#8217;s<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> Lerner Research Institute and co-section head of Preventive Cardiology at the Heart, Vascular &amp; Thoracic Institute. <\/mark><em><mark class=\"has-inline-color has-vivid-cyan-blue-color\">&#8220;What&#8217;s more, we can measure it, which means there is potential for diagnostic tests. These insights set the stage for developing new approaches to counter the effects of this pathway.&#8221;<\/mark><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Niacin<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"><strong> (vitamin B-3)<\/strong> is very common in the Western diet. <\/mark><em><mark class=\"has-inline-color has-vivid-cyan-blue-color\">&#8220;For decades, the United States and more than 50 other countries have mandated niacin fortification of staple foods such as flour, cereals and oats to prevent diseases related to nutritional deficiency,&#8221;<\/mark><\/em><mark class=\"has-inline-color has-black-color\"> said<\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\"> Dr. Hazen.<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> However, in the researchers&#8217; patient cohorts, one in four subjects appears to be getting too much and has high levels of <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">4PY,<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> which appears to contribute to the development of cardiovascular disease.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Dr. Hazen<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> compares our niacin intake to several taps pouring water into a bucket. Once the bucket is full, it starts to overflow. The human body then needs to process that overflow and produces other metabolites, including <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">4PY.<\/mark><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><mark class=\"has-inline-color has-vivid-cyan-blue-color\">&#8220;The main takeaway is not that we should cut out niacin entirely \u2013 that&#8217;s not a realistic approach,&#8221; <\/mark><\/em><mark class=\"has-inline-color has-black-color\">said <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Dr. Hazen.<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> <\/mark><mark class=\"has-inline-color has-vivid-cyan-blue-color\"><em>&#8220;Given these findings, a discussion could be considered on whether continued niacin fortification of flour and cereals is warranted in the United States.&#8221;<\/em><\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\"> Dr. Hazen<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> notes that the more widespread use of<\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\"> over-the-counter supplements <\/mark><\/strong><mark class=\"has-inline-color has-black-color\">made with different forms of niacin has also become popular because of their supposed anti-ageing benefits. He adds that <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">patients should talk to their doctors before taking over-the-counter supplements<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> and focus on a diet rich in fruit and vegetables, avoiding excess carbohydrates.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-black-color\">The <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">new findings<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> could also help explain why<strong> <\/strong><\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">niacin<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"><strong> is no longer considered a preferred treatment for lowering cholesterol.<\/strong><\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\"> Niacin<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> was one of the first treatments prescribed to lower LDL, or &#8220;bad&#8221; cholesterol. Eventually, however,<strong> <\/strong><\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">niacin<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"><strong> was shown to be less effective than other drugs<\/strong> for lowering cholesterol and was associated with other negative effects and higher mortality rates in previous research.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><mark class=\"has-inline-color has-vivid-cyan-blue-color\">&#8220;Niacin&#8217;s effects have always been somewhat paradoxical,&#8221;<\/mark><\/em><mark class=\"has-inline-color has-black-color\"> said<\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\"> Dr. Hazen.<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> <\/mark><em><mark class=\"has-inline-color has-vivid-cyan-blue-color\">&#8220;Despite lowering cholesterol, the clinical benefits have always been less than expected given the degree of LDL reduction. This led to the idea that excess niacin causes unclear adverse effects that partially offset the benefits of lowering LDL. We believe our findings help explain this paradox. This shows why investigating residual cardiovascular risk is so critical; we learn so much more than what we set out to find.&#8221;<\/mark><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-black-color\">The study authors note that long-term research is needed to assess the effect of chronically raised <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">4PY <\/mark><\/strong><mark class=\"has-inline-color has-black-color\">levels on atherosclerosis and other phenotypes.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-black-color\">This research is part of<\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\"> Dr. Hazen&#8217;s<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> ongoing work to identify contributors to residual cardiovascular risk. His team follows patients over the long term, collecting blood samples to identify chemical signatures that can predict the development of heart disease. Throughout his career, he has made pioneering discoveries in atherosclerosis and inflammatory disease research, including the seminal discovery linking gut microbial pathways with cardiovascular and metabolic diseases.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Dr. Hazen<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> also directs <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Cleveland Clinic&#8217;s Center for Microbiome and Human Health<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> and holds the Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Marc Ferrell,<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> a former <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">M.D., Ph.D.<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> student in <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Dr. Hazen&#8217;s<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> lab and a student in <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Case Western Reserve University&#8217;s Medical Scientist Training Program,<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> is the first author of the manuscript. The research reported in this publication was supported in part by the <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">National Institutes of Health <\/mark><\/strong><mark class=\"has-inline-color has-black-color\">under grant numbers R01HL103866, P01HL147823, R01HL133169, R01HL148110, R01HL168493 and U54HL170326.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>About Cleveland Clinic<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"250\" height=\"250\" src=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2019\/06\/Cleveland.jpg\" alt=\"Cleveland Clinic\" class=\"wp-image-2354\" srcset=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2019\/06\/Cleveland.jpg 250w, https:\/\/afcomunicacion.com\/wp-content\/uploads\/2019\/06\/Cleveland-150x150.jpg 150w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Cleveland Clinic<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> is a nonprofit multispecialty academic medical centre that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based on the principles of cooperation, compassion and innovation. <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Cleveland Clinic<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"><strong> has pioneered many medical breakthroughs,<\/strong> including coronary artery bypass surgery and the first face transplant in the United States. Among <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Cleveland Clinic&#8217;s <\/mark><\/strong><mark class=\"has-inline-color has-black-color\">77,000 employees worldwide are more than 5,658 salaried physicians and researchers, and 19,000 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties.<\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\"> Cleveland Clinic<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> is a 6,699-bed health system that includes a 173-acre main campus near downtown Cleveland, 23 hospitals, more than 275 outpatient facilities, including locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2022, there were 12.8 million outpatient encounters, 303,000 hospital admissions and observations, and 270,000 surgeries and procedures throughout <\/mark><strong><mark class=\"has-inline-color has-vivid-cyan-blue-color\">Cleveland Clinic&#8217;s<\/mark><\/strong><mark class=\"has-inline-color has-black-color\"> health system. Patients came for treatment from every state and 185 countries.<\/mark><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The new findings could also help explain why niacin is no longer considered a preferred treatment for lowering cholesterol. Niacin was one of the first treatments prescribed to lower LDL, or &#8220;bad&#8221; cholesterol. Eventually, however, niacin was shown to be less effective than other cholesterol-lowering drugs and was associated with other negative effects and higher mortality rates in previous research.<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[486],"tags":[2230,3097,3516,3517,2224,3518],"class_list":["post-12972","post","type-post","status-publish","format-standard","hentry","category-press-room","tag-cleveland-en","tag-colesterol-en","tag-estudios-en","tag-niacina-en","tag-salud-en","tag-vitamina-b3-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.3 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>The dangers of excess niacin for cardiovascular health - AF Comunicaci\u00f3n Estrat\u00e9gica<\/title>\n<meta name=\"description\" content=\"Discover how excess niacin can contribute to cardiovascular disease. Learn about the newly identified pathway.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cleveland Clinic-led study finds link between high levels of niacin - a common B vitamin - and heart disease\" \/>\n<meta property=\"og:description\" content=\"Discover how excess niacin can contribute to cardiovascular disease. Learn about the newly identified pathway.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"AF Comunicaci\u00f3n Estrat\u00e9gica\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/afcomunicacionestrategica\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-07T16:49:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"AF Comunicaci\u00f3n Estrat\u00e9gica\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@AFComunicacion\" \/>\n<meta name=\"twitter:site\" content=\"@AFComunicacion\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"AF Comunicaci\u00f3n Estrat\u00e9gica\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/\"},\"author\":{\"name\":\"AF Comunicaci\u00f3n Estrat\u00e9gica\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#\\\/schema\\\/person\\\/fe64955688913b2174ea1635745e7379\"},\"headline\":\"Cleveland Clinic-led study finds link between high levels of niacin &#8211; a common B vitamin &#8211; and heart disease\",\"datePublished\":\"2024-03-07T16:49:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/\"},\"wordCount\":945,\"publisher\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/afcomunicacion.com\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg\",\"keywords\":[\"Cleveland\",\"colesterol\",\"estudios\",\"niacina\",\"Salud\",\"vitamina b3\"],\"articleSection\":[\"Press Room\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/\",\"url\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/\",\"name\":\"The dangers of excess niacin for cardiovascular health - AF Comunicaci\u00f3n Estrat\u00e9gica\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/afcomunicacion.com\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg\",\"datePublished\":\"2024-03-07T16:49:51+00:00\",\"description\":\"Discover how excess niacin can contribute to cardiovascular disease. Learn about the newly identified pathway.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/#primaryimage\",\"url\":\"https:\\\/\\\/afcomunicacion.com\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg\",\"contentUrl\":\"https:\\\/\\\/afcomunicacion.com\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/press-room\\\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cleveland Clinic-led study finds link between high levels of niacin &#8211; a common B vitamin &#8211; and heart disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/\",\"name\":\"AF Comunicaci\u00f3n Estrat\u00e9gica\",\"description\":\"Agencia especializada en consultor\u00eda de Comunicaci\u00f3n Estrat\u00e9gica, Relaciones P\u00fablicas y Eventos Corporativos.\",\"publisher\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#organization\",\"name\":\"AF Comunicaci\u00f3n Estrat\u00e9gica\",\"url\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"AF Comunicaci\u00f3n Estrat\u00e9gica\"},\"image\":{\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/afcomunicacionestrategica\",\"https:\\\/\\\/x.com\\\/AFComunicacion\",\"https:\\\/\\\/www.instagram.com\\\/afcomunicacion\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/afcomunicacion\\\/?viewAsMember=true\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCb0JkclVAyd3M9SzeiiNJAg\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/#\\\/schema\\\/person\\\/fe64955688913b2174ea1635745e7379\",\"name\":\"AF Comunicaci\u00f3n Estrat\u00e9gica\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/85f2cc1a31c5a2575f1b79ad47644a448b6cdfff59769f0219f7f09f29871d9e?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/85f2cc1a31c5a2575f1b79ad47644a448b6cdfff59769f0219f7f09f29871d9e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/85f2cc1a31c5a2575f1b79ad47644a448b6cdfff59769f0219f7f09f29871d9e?s=96&d=mm&r=g\",\"caption\":\"AF Comunicaci\u00f3n Estrat\u00e9gica\"},\"url\":\"https:\\\/\\\/afcomunicacion.com\\\/en\\\/author\\\/dgonzalez\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"The dangers of excess niacin for cardiovascular health - AF Comunicaci\u00f3n Estrat\u00e9gica","description":"Discover how excess niacin can contribute to cardiovascular disease. Learn about the newly identified pathway.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/","og_locale":"en_US","og_type":"article","og_title":"Cleveland Clinic-led study finds link between high levels of niacin - a common B vitamin - and heart disease","og_description":"Discover how excess niacin can contribute to cardiovascular disease. Learn about the newly identified pathway.","og_url":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/","og_site_name":"AF Comunicaci\u00f3n Estrat\u00e9gica","article_publisher":"https:\/\/www.facebook.com\/afcomunicacionestrategica","article_published_time":"2024-03-07T16:49:51+00:00","og_image":[{"width":2560,"height":1707,"url":"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-scaled.jpg","type":"image\/jpeg"}],"author":"AF Comunicaci\u00f3n Estrat\u00e9gica","twitter_card":"summary_large_image","twitter_creator":"@AFComunicacion","twitter_site":"@AFComunicacion","twitter_misc":{"Written by":"AF Comunicaci\u00f3n Estrat\u00e9gica","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/#article","isPartOf":{"@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/"},"author":{"name":"AF Comunicaci\u00f3n Estrat\u00e9gica","@id":"https:\/\/afcomunicacion.com\/en\/#\/schema\/person\/fe64955688913b2174ea1635745e7379"},"headline":"Cleveland Clinic-led study finds link between high levels of niacin &#8211; a common B vitamin &#8211; and heart disease","datePublished":"2024-03-07T16:49:51+00:00","mainEntityOfPage":{"@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/"},"wordCount":945,"publisher":{"@id":"https:\/\/afcomunicacion.com\/en\/#organization"},"image":{"@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg","keywords":["Cleveland","colesterol","estudios","niacina","Salud","vitamina b3"],"articleSection":["Press Room"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/","url":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/","name":"The dangers of excess niacin for cardiovascular health - AF Comunicaci\u00f3n Estrat\u00e9gica","isPartOf":{"@id":"https:\/\/afcomunicacion.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/#primaryimage"},"image":{"@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg","datePublished":"2024-03-07T16:49:51+00:00","description":"Discover how excess niacin can contribute to cardiovascular disease. Learn about the newly identified pathway.","breadcrumb":{"@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/#primaryimage","url":"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg","contentUrl":"https:\/\/afcomunicacion.com\/wp-content\/uploads\/2024\/03\/Dr.-Stanley-Hazen-presidente-de-Ciencias-Cardiovasculares-y-Metabolicas-en-el-Instituto-de-Investigacion-Lerner-de-Cleveland-Clinic-1024x683.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/afcomunicacion.com\/en\/press-room\/cleveland-clinic-led-study-finds-link-between-high-levels-of-niacin-a-common-b-vitamin-and-heart-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/afcomunicacion.com\/en\/"},{"@type":"ListItem","position":2,"name":"Cleveland Clinic-led study finds link between high levels of niacin &#8211; a common B vitamin &#8211; and heart disease"}]},{"@type":"WebSite","@id":"https:\/\/afcomunicacion.com\/en\/#website","url":"https:\/\/afcomunicacion.com\/en\/","name":"AF Comunicaci\u00f3n Estrat\u00e9gica","description":"Agencia especializada en consultor\u00eda de Comunicaci\u00f3n Estrat\u00e9gica, Relaciones P\u00fablicas y Eventos Corporativos.","publisher":{"@id":"https:\/\/afcomunicacion.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/afcomunicacion.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/afcomunicacion.com\/en\/#organization","name":"AF Comunicaci\u00f3n Estrat\u00e9gica","url":"https:\/\/afcomunicacion.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/afcomunicacion.com\/en\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"AF Comunicaci\u00f3n Estrat\u00e9gica"},"image":{"@id":"https:\/\/afcomunicacion.com\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/afcomunicacionestrategica","https:\/\/x.com\/AFComunicacion","https:\/\/www.instagram.com\/afcomunicacion\/","https:\/\/www.linkedin.com\/company\/afcomunicacion\/?viewAsMember=true","https:\/\/www.youtube.com\/channel\/UCb0JkclVAyd3M9SzeiiNJAg"]},{"@type":"Person","@id":"https:\/\/afcomunicacion.com\/en\/#\/schema\/person\/fe64955688913b2174ea1635745e7379","name":"AF Comunicaci\u00f3n Estrat\u00e9gica","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/85f2cc1a31c5a2575f1b79ad47644a448b6cdfff59769f0219f7f09f29871d9e?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/85f2cc1a31c5a2575f1b79ad47644a448b6cdfff59769f0219f7f09f29871d9e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/85f2cc1a31c5a2575f1b79ad47644a448b6cdfff59769f0219f7f09f29871d9e?s=96&d=mm&r=g","caption":"AF Comunicaci\u00f3n Estrat\u00e9gica"},"url":"https:\/\/afcomunicacion.com\/en\/author\/dgonzalez\/"}]}},"_links":{"self":[{"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/posts\/12972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/comments?post=12972"}],"version-history":[{"count":0,"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/posts\/12972\/revisions"}],"wp:attachment":[{"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/media?parent=12972"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/categories?post=12972"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/afcomunicacion.com\/en\/wp-json\/wp\/v2\/tags?post=12972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}